It is a very powerful magnum, and will have unlimited ammunition. The HandCannon will be available as soon as you start the game again for 0 Pesetas. Alternately, successfully complete the game two times. To get unlimited ammunition for it, fully upgrade all of the HandCannon's options. Get a five star rank with all mercenaries in the Mercenaries mini-game to unlock the HandCannon weapon. Successfully complete the Separate Ways mini-game to unlock the Chicago Typewriter (Tommy gun with infinite ammunition) for purchase (for 1 million Pesetas). The merchant will give you a PRL 412 laser cannon when you start Round 2 of Professional mode. Successfully complete the game in Professional mode. You do not have to worry about giving her First Aid Sprays, Herbs, or shooting Ganados trying to pick her up. She cannot get hurt by anything and it is so heavy she cannot be carried away. Ashley's suit of armor is bullet and damage proof. Successfully complete the Separate Ways mini-game to unlock Ashley's knight costume and Leon's gangster costume. Once you start the game, all of your items from your previous game will be in your item box. Once you choose that file, you will be taken to a menu where you can buy the Matilda Handgun or the Infinite Rocket Launcher.

After completing the game the first time, start a new game, then press Start and select 'Load Game'. Successfully complete the game to unlock the Separate Ways and Mercenaries mini-games the Professional difficulty setting Leon's Raccoon City Police Department costume, Ashley's pop star costume, and Ada's black costume the Mathilda handgun and Infinite Rocket Launcher for purchase (for 1 million Pesetas), and the Tactical Vest (for 60,000 Pesetas) and an alternate title screen.

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